![]() ![]() It is very important to tell your care team at the first sign of HFS. These blisters become very painful and can interfere with daily activities. If there is no change in the treatment, the hands and/or feet can blister, which can then become infected. HFS can start as a feeling of tingling or numbness in the palms and/or soles, which leads to swelling, redness, peeling skin, and tenderness or pain. Chemotherapy drugs known to cause HFS include: capecitabine (Xeloda®), fluorouracil (5-FU), liposomal doxorubicin (Doxil®), doxorubicin (Adriamycin®), cytarabine (Ara-c®), sunitinib (Sutent®) and sorafenib (Nexavar®). It may also be referred to as acral erythema, palmar plantar erythema (PPE), or Burgdorf reaction. Hand-foot syndrome (HFS) is a skin reaction on the palms of the hands and/or the soles of the feet as a result of certain chemotherapy agents. ![]() O-Pro: Portal for Oncology Professionals. ![]()
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